Antihypertensive activity and acute toxicity of turmeric (Curcuma longa L.) in L-NAME-induced hypertension animals

Hypertension is one of the significant risk factors for cardiovascular disease and can lead to complications. Uncontrolled hypertension vascular endothelial dysfunction other complications disease. This study aimed determine effect turmeric rhizome (Curcuma longa L.) in extracts fractions on a hypertensive rat’s model induced by L-NAME 40 mg/kg three weeks an acute toxicity extract. Antihypertensive research was performed male Wistar rats utilizing non-invasive procedures. Turmeric extract at doses 50, 100, 200 its fraction n-hexane, acetyl acetate, ethanol dose 25 mg/kg, respectively, were given daily per oral 2.5 captopril. The systolic diastolic blood pressure measured 0, 21, 42 days after treatment calculated as mean arterial (MAP). Acute testing refers OECD 420 Fixed-Dose method with several dosage levels, consists 300, 2000, 5000 mg/kg. significantly reduced (p<0.05) compared control group. administration up test animals did not show any death. components are considered possess antihypertensive actions. activity increased dose-dependent manner. categorized being almost entirely non-toxic.